IFN-γ Protects Cerulein-Induced Acute Pancreatitis by Repressing NF-κB Activation

IFN- Protects Cerulein-Induced Acute Pancreatitis by Repressing NF- B Activation

Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB.

Diosmetin (3', 5, 7-trihydroxy-4'-methoxyflavone), the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit, was considered to exhibit anti-inflammatory and antioxidant properties. Our study aimed to investigate the effect of diosmetin in a murine model of cerulein-induced acute pancreatitis (AP). Experimental AP was induced in mice by seven intraperitoneal injecti...

Early NF-κB activation is associated with hormone-induced pancreatitis.

Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-κB (NF-κB), which regulates these processes, is activated and plays a role in rat cerulein pancreatitis. NF-κB was strongly activated in the pancreas within 30 min of cerulein infusion; a second phase of NF-κB activation was prominent at 3-6 h. This biphasic kine...

Constitutive silencing of IFN-β promoter is mediated by NRF (NF-κB-repressing factor), a nuclear inhibitor of NF-κB

Transcriptional regulation of the interferon-β (IFN-β) gene is characterized by strict constitutive repression and virus-specific activation. Previous studies have shown that the IFN-β promoter is constitutively repressed by a negative regulatory element (NRE). Isolated NRE acts as a constitutive and positionindependent silencer on the NF-κB-binding sites. Here, we describe the identification a...

Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice

Objective(s): Endometritis is the inflammation of the uterine lining that is associated with infertility. It affects milk production and reproductive performance and leads to huge economic losses in dairy cows. Dimethyl itaconate (DI), a promising chemical agent, has recently been proved to have multiple health-promoting effects. However, the effects of DI on endometri...